<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Montenegro, M. M.</style></author><author><style face="normal" font="default" size="100%">Ribeiro, I. W. J.</style></author><author><style face="normal" font="default" size="100%">Kampits, C.</style></author><author><style face="normal" font="default" size="100%">Saffi, M. A. L.</style></author><author><style face="normal" font="default" size="100%">Furtado, M. V.</style></author><author><style face="normal" font="default" size="100%">Polanczyk, C. A.</style></author><author><style face="normal" font="default" size="100%">Haas, A. N.</style></author><author><style face="normal" font="default" size="100%">Rosing, C. K.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: Preliminary findings of 3 months</style></title><secondary-title><style face="normal" font="default" size="100%">J Clin Periodontol</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*C-reactive protein</style></keyword><keyword><style  face="normal" font="default" size="100%">*cardiovascular disease</style></keyword><keyword><style  face="normal" font="default" size="100%">*Cardiovascular Diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">*Coronary Artery Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">*cytokines</style></keyword><keyword><style  face="normal" font="default" size="100%">*periodontal disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Biomarkers</style></keyword><keyword><style  face="normal" font="default" size="100%">C-Reactive Protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Single-Blind Method</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Mar</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/30761568</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">3</style></number><edition><style face="normal" font="default" size="100%">2019/02/15</style></edition><volume><style face="normal" font="default" size="100%">46</style></volume><pages><style face="normal" font="default" size="100%">321-331</style></pages><isbn><style face="normal" font="default" size="100%">1600-051X (Electronic)0303-6979 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;AIM: To assess the effect of periodontal therapy (PT) on cardiovascular blood biomarkers. MATERIALS AND METHODS: This single-blind, parallel-design, randomized controlled trial included patients with stable coronary artery disease and periodontitis. The test group (TG) received non-surgical PT, whereas the control group (CG) received one session of plaque removal. Plasma levels of C-reactive protein (CRP), glycated haemoglobin, lipids and cytokines (IL-1beta, IL-6, IL-8, IL-10, IFN-gamma and TNF-alpha) were measured at baseline and after 3 months. RESULTS: Eighty-two patients (74.4% women, mean age 59.6 years) were analysed. TG had significantly better periodontal parameters than CG after 3 months, but no significant differences in blood markers were observed between them. In a post hoc subgroup analysis in patients with baseline CRP &amp;lt;3 mg/L, a significant increase in CRP was observed in CG (1.44 +/- 0.82 mg/L to 4.35 +/- 7.85 mg/L, p = 0.01), whereas CRP remained unchanged in TG (1.40 +/- 0.96 mg/L to 1.33 +/- 1.26 mg/L, p = 0.85), resulting in a significant difference between groups at 3 months. In patients with CRP &amp;gt;/=3 mg/L, a significant reduction in CRP was observed only in TG (11.3 +/- 12.8 mg/L to 5.7 +/- 4.1 mg/L, p = 0.04). Levels of IL-6 and IL-8 were significantly lower in TG than CG at 3 months. CONCLUSIONS: PT leads to lower levels of CRP, IL-6 and IL-8 in cardiovascular patients with high CRP levels.&lt;/p&gt;
</style></abstract><accession-num><style face="normal" font="default" size="100%">30761568</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;Montenegro, Marlon MRibeiro, Ingrid W JKampits, CassioSaffi, Marco A LFurtado, Mariana VPolanczyk, Carisi AHaas, Alex NRosing, Cassiano KengRandomized Controlled TrialResearch Support, Non-U.S. Gov'tJ Clin Periodontol. 2019 Mar;46(3):321-331. doi: 10.1111/jcpe.13085. Epub 2019 Mar 6.&lt;/p&gt;
</style></notes><auth-address><style face="normal" font="default" size="100%">Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.Cardiology Division, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.Service of Cardiology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.</style></auth-address></record></records></xml>