<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haas, A. N.</style></author><author><style face="normal" font="default" size="100%">Silva-Boghossian, C. M.</style></author><author><style face="normal" font="default" size="100%">Colombo, A. P.</style></author><author><style face="normal" font="default" size="100%">Susin, C.</style></author><author><style face="normal" font="default" size="100%">Albandar, J. M.</style></author><author><style face="normal" font="default" size="100%">Oppermann, R. V.</style></author><author><style face="normal" font="default" size="100%">Rosing, C. K.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Adjunctive azithromycin in the treatment of aggressive periodontitis: microbiological findings of a 12-month randomized clinical trial</style></title><secondary-title><style face="normal" font="default" size="100%">J Dent</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Journal of dentistry</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Root Planing</style></keyword><keyword><style  face="normal" font="default" size="100%">Actinomyces/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aggressive Periodontitis/microbiology/*therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-Bacterial Agents/*therapeutic use</style></keyword><keyword><style  face="normal" font="default" size="100%">Azithromycin/*therapeutic use</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacteria/classification/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Capnocytophaga/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Dental Plaque/microbiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Dental Scaling/*methods</style></keyword><keyword><style  face="normal" font="default" size="100%">Double-Blind Method</style></keyword><keyword><style  face="normal" font="default" size="100%">Eikenella corrodens/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Eubacterium/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Follow-Up Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Fusobacterium nucleatum/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Fusobacterium/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Placebos</style></keyword><keyword><style  face="normal" font="default" size="100%">Prevotella intermedia/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptococcus gordonii/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment Outcome</style></keyword><keyword><style  face="normal" font="default" size="100%">Treponema denticola/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Veillonella/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Young Adult</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/22445846</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">7</style></number><volume><style face="normal" font="default" size="100%">40</style></volume><pages><style face="normal" font="default" size="100%">556-63</style></pages><isbn><style face="normal" font="default" size="100%">1879-176X (Electronic)0300-5712 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;OBJECTIVES: To compare the subgingival microbiological outcomes of azithromycin or placebo as adjuncts to scaling and root planing (SRP) in the treatment of aggressive periodontitis (AgP), and to secondarily evaluate the microbiological effect of supragingival scaling in AgP patients. METHODS: Twenty-four AgP subjects 13-26 years of age received a 15-day programme of supragingival scaling (SC) and were then randomly assigned to SRP with systemic azithromycin or placebo. Subgingival samples were taken with sterile paper points at baseline, 15 days after SC, and at 3, 6 and 12 months following SRP. Microbiological analysis was performed by the checkerboard DNA-DNA hybridization. RESULTS: Changes in bacterial levels from baseline to 15 days after SC were similar in the 2 groups. When subjects were analysed as a single group, significant reductions after SC were observed for Actinomyces gerencseriae, Capnocytophaga ochracea, and Treponema denticola. During the 12-month follow-up, levels of most of the bacteria decreased in both groups in a similar pattern. For instance, Actinomyces israelli, Veillonella parvula, Streptococcus gordonii, C. ochracea, Eikenella corrodens, Eubacterium nodatum, Fusobacterium periodonticum and Fusobacterium nucleatum ssp. polymorphum decreased significantly within the groups. CONCLUSIONS: Azithromycin was ineffective in lowering the subgingival levels of important putative periodontal pathogens in young AgP subjects compared to placebo. CLINICAL SIGNIFICANCE: Scaling and root planing with adjunctive systemic azithromycin provides little additional benefit compared to placebo in reductions of major subgingival periodontal pathogens.&lt;/p&gt;
</style></abstract><accession-num><style face="normal" font="default" size="100%">22445846</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;Haas, Alex NogueiraSilva-Boghossian, Carina MacielColombo, Ana PaulaSusin, CristianoAlbandar, Jasim MOppermann, Rui VicenteRosing, Cassiano KuchenbeckerengComparative StudyRandomized Controlled TrialResearch Support, Non-U.S. Gov'tEngland2012/03/27 06:00J Dent. 2012 Jul;40(7):556-63. doi: 10.1016/j.jdent.2012.03.004. Epub 2012 Mar 20.&lt;/p&gt;
</style></notes><auth-address><style face="normal" font="default" size="100%">Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. alexnhaas@gmail.com</style></auth-address></record></records></xml>