<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Brito, V.B.</style></author><author><style face="normal" font="default" size="100%">Rocha, J. B. T.</style></author><author><style face="normal" font="default" size="100%">Folmer, V.</style></author><author><style face="normal" font="default" size="100%">Erthal, F.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">{Diphenyl diselenide and diphenyl ditelluride increase the latency for 4-aminopyridine-induced chemical seizure and prevent death in mice}</style></title><secondary-title><style face="normal" font="default" size="100%">Acta Biochimica Polonica</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">4-aminopyridine</style></keyword><keyword><style  face="normal" font="default" size="100%">Diphenyl diselenide</style></keyword><keyword><style  face="normal" font="default" size="100%">Diphenyl ditelluride</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Seizure</style></keyword><keyword><style  face="normal" font="default" size="100%">Selenium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year></dates><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">56</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;In this work was investigated the effect of pre-treatment with (PhSe) 2 and (PhTe) 2 on chemical seizure and 4-aminopyridine-induced lethality in mice. Additionally, lipid peroxidation levels of whole brain after treatment with 4-aminopyridine and effect of pre-treatment with (PhSe) 2 and (PhTe) 2 on these levels were investigated. Mice were pre-treated with (PhSe) 2 or (PhTe) 2 (50, 100, or 150 $μ$mol/kg) 30 min before 4-aminopyridine (12 mg/kg) administration. The treatment with 4-aminopyridine caused a significant incidence of seizures (clonic, tonic) and death. Pre-treatment with (PhSe) 2 and (PhTe) 2 significantly increased the latency for clonic and tonic seizures, and prevented 4-aminopyridine-induced death. Significantly, the pre-treatment with (PhSe) 2 or (PhTe) 2 increased the latency for clonic seizures in a dose-dependent manner. Additionally, a significant increase was observed in the brain lipid peroxidation level after treatment with 4-aminopyridine, which was significantly inhibited by pre-treatment with 150 $μ$mol/kg (PhSe) 2 or (PhTe) 2 . These results demonstrate that (PhSe) 2 and (PhTe) 2 counteract the harmful effects of 4-aminopyridine. It is possible that this effect results from modulation of the redox state of N-methyl-d-aspartate receptors and/or of Ca 2+ channel activity with subsequent alteration in neurotransmitter release. Importantly, this study provides evidence for anticonvulsant and antioxidant properties of (PhSe) 2 and (PhTe) 2′ which indicates a neuroprotective activity of these compounds.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record></records></xml>