<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gonçalves, T.L.</style></author><author><style face="normal" font="default" size="100%">Erthal, F.</style></author><author><style face="normal" font="default" size="100%">Corte, C.L.D.</style></author><author><style face="normal" font="default" size="100%">Müller, L.G.</style></author><author><style face="normal" font="default" size="100%">Piovezan, C.M.</style></author><author><style face="normal" font="default" size="100%">Nogueira, C.W.</style></author><author><style face="normal" font="default" size="100%">Rocha, J. B. T.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">{Involvement of oxidative stress in the pre-malignant and malignant states of cervical cancer in women}</style></title><secondary-title><style face="normal" font="default" size="100%">Clinical Biochemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ALA-D</style></keyword><keyword><style  face="normal" font="default" size="100%">Cervical cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Pre-malignant states</style></keyword><keyword><style  face="normal" font="default" size="100%">TBARS</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin C</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year></dates><number><style face="normal" font="default" size="100%">12</style></number><volume><style face="normal" font="default" size="100%">38</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Objectives: To evaluate the potential role of oxidative stress in the evolution of cervical cancer, including its pre-malignant states. Design and methods: Erythrocytes thiobarbituric acid reactive substances (TBARS) levels, plasma vitamin C and thiol content and total blood $δ$-ALA-D levels were estimated in 46 untreated cervical cancer and pre-malignant patients and in 46 age-sex-matched controls. Results: Erythrocytes from patients, regardless of disease state, pre-malignant (low squamous intraepithelial lesion-LSIL and high squamous intraepithelial lesion-HSIL) or cancer, showed a significant 2-3 times increase in TBARS levels (P {\textless} 0.01). Plasma vitamin C was lower in the carcinoma group (P {\textless} 0.01). The reactivation index of $δ$-aminolevulinate dehydratase ($δ$-ALA-D) was higher in the patient group, when compared to control (P {\textless} 0.01). Conclusion: LSIL, HSIL or cervical cancer can be associated with changes in 3 indicators of oxidative stress: increase in erythrocyte TBARS, ALA-D reactivation index and a decrease in vitamin C content, that may play an important role in carcinogenesis. © 2005 The Canadian Society of Clinical Chemists. All rights reserved.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record></records></xml>